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Pandemic will not end for anyone, ‘until it ends for everyone’

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The COVID-19 pandemic “will not end for anyone, until it ends for everyone”, an independent UN human rights expert said on Friday, advocating for an equitable and globally-coordinated vaccine distribution programme. 

“The virus can still travel from the vastly unvaccinated massive population of the Global South to the Global North, including in its increasingly mutating forms”, Obiora Okafor, UN Special Rapporteur on human rights and international solidarity, said in a statement

He explained that with mutations constantly evolving, only inoculating rich countries would likely “complicate or delay” the eradication of the virus. 

Skewed vaccine delivery 

The last few weeks of 2020 witnessed the approval of several COVID-19 vaccines by regulators in various countries, “offering much hope to billions of people worldwide”, according to the UN expert.  

And while several States, mostly in the north, have already secured large quantities of vaccine and have begun inoculation campaigns, this has not been the case for most of the Global South, where close to 90 per cent of the world’s population lives. 

“The world, therefore, faces a sharp and highly problematic vaccine-divide in which the much richer Global North States, which host a very small percentage of the global population, have so far cornered the vast majority of available COVID-19 vaccines, leaving the bulk of the world’s population with almost no access to these medicines”, Mr. Okafor said.  

“A globally coordinated vaccine distribution programme is highly preferable to the individualized approaches adopted by all-too-many of the richer States”, Mr. Okafor said. 

International vaccine solidarity  

He said it was vital that States and non-State actors cooperate – such as through the COVID-19 Vaccine Global Access Facility (COVAX), which, led by the World Health Organization (WHO), is part of the Access to COVID-19 Tools (ACT) Accelerator – or risk a stalled recovery. 

While noting that COVAX aims to fairly distribute two billion vaccine doses by the end of 2021, Mr. Okafor emphasized that “international vaccine solidarity” be favored over “international vaccine competition”. 

“Given the great urgency of ensuring for everyone, everywhere, as rapid and effective access to COVID-19 vaccines as possible, I, therefore, urge urgent and strong action by States and other actors toward a course correction”, he said. 

Click here for the names of the UN experts who endorsed the statement. 

Fair access for migrants 

Separately, UN independent experts González Morales and Tlaleng Mofokeng have urged States to ensure that migrants are also included in national COVID vaccination programmes, saying that global immunization access for everyone who needs them “is the only solution” to ending the pandemic. 

This includes priority groups of vulnerable people “regardless of who they are” or their migration status, said the rights experts. 

They also called on world leaders to refrain from discriminatory discourse that could lead to the exclusion of migrants in irregular situations from the global public health response. 

Special Rapporteurs and independent experts are appointed by the Geneva-based UN Human Rights Council and are neither UN staff nor paid for their work.  

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Easier, early cervical cancer testing to save lives

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by Alex Whiting

Prevention and the HPV vaccine is helping to reduce the numbers of women dying with cervical cancer but new portable screening kits and new types of lab tests will improve diagnosis and earlier treatment of the disease.

New advances in screening for cervical cancer – the fourth most common cancer among women – have the potential to save many women’s lives, their developers say.

While outcomes for women with cervical cancer have improved overall in recent years, the death toll from the disease is still too high. Despite the fact that cervical cancer is highly treatable if diagnosed early enough, more than 340 000 women died of the disease in 2020.

The majority of deaths occur in low- and middle-income countries where women often have limited access to screening services, according to the World Health Organizaton.

Even when women do get tested, there can be a delay of several months before they get the result and, if they test positive, another delay before they receive treatment.
‘If you have already an advanced stage of the cancer, these months can be the difference between life or death,’ says Olivier Degomme, coordinator of a project called ELEVATE, which is developing a portable screening kit to take to deprived areas.

‘We really want to reduce this interval of months to an interval of ideally 24 hours,’ he says.

Mobile kit

ELEVATE’s mobile kit is designed for use in communities with limited access to medical care. Health workers would explain the importance of getting screened, then offer the test and be able to give women the results within a day.

The kit requires little training to use. Women collect a sample themselves, which the health workers run through the battery-powered analysis unit. The unit uses a DNA test to check for the presence of high-risk human papillomavirus (HPV) infections, which can lead to cervical cancer. Results are returned within minutes.

The researchers aim to begin using the toolkit in mountain villages and deprived urban areas in Ecuador and Brazil. They also want to use it with hard-to-reach women in Belgium and Portugal.

Initially, the researchers focused on migrant and other marginalised communities which have difficulty accessing medical care or which may not know about the importance of being screened.

Too busy

But they also found that highly educated career women were not going for screening because they were too busy. So, as well as taking the testing kit to deprived communities, it could also be useful in busy offices, for example.

‘At the global level, the gains will be much higher with focusing on hard-to-reach women in poorer communities. But a nice side-effect (of the project) is that we could also use this in groups of highly educated women,’ says Prof. Degomme, who is associate professor at the faculty of medicine and health sciences at Ghent University, Belgium.

Screening programmes vary between countries. Some invite all women of eligible age to get tested. Some offer opportunistic screening where a patient is told about and offered screening when she visits a clinic. Some countries do not screen at all.

The WHO has set 2030 targets to reduce cervical cancer rates worldwide. One of these is for 70% of women to be screened with a high-performance test by 35, and again by 45 years of age.

Prof Degomme hopes ELEVATE’s portable kit will help countries meet the WHO target. It still has to be tested in the field, and assessed for its acceptability, feasibility and cost-effectiveness for low-income countries.

‘The important thing is to make sure that it will reach women who could not otherwise be reached. And we can actually save lives, hopefully many lives’, he said.

Ramen analysis

The HPV virus has more than 100 different strains, 14 of which are considered high risk for cervical cancer. Increasingly, countries with screening programmes test for high-risk HPV infections.

Researchers have recently designed a test that can distinguish between an infection that will resolve itself and one which will become chronic and possibly lead to cancer.

They use Raman spectroscopy to check for changes in the molecular make-up of cervical cells taken during a smear test.

Ramen spectroscopy is a scanning technique for identifying the chemical composition of materials by measuring their vibrational response to laser light. The research involves shining a light on the cells to make their molecules vibrate.

The resulting vibration ‘fingerprint’ gives an indication of whether the cell content has been changed by the virus.

Cell specialist

Currently, if someone tests positive for a high-risk HPV infection, their cervical cells are checked through a microscope. These checks are done by a specialist in cells, called a cytologist.

The cell may look fine down the microscope, but Raman spectroscopy may pick up changes on a molecular level which are invisible to the human eye, according to Prof Fiona Lyng, coordinator of a project called ARC-HPV.

The project, which ended in 2018, concluded that Raman spectroscopy could be used to test for infections that could lead to cancer. Its findings have now been patented.

Since 2018, researchers have tested the method on larger samples and found it was at least 91% accurate in differentiating between cells of concern and those which are likely to recover from infection.

The next step will be to test the accuracy of Raman spectroscopy in an entire population being screened.

Vaccination success

Another important form of prevention is vaccination. Available vaccines are highly effective, but they do not protect against all forms of high-risk HPV. 

‘The vaccine will really reduce cervical pre-cancers and cancers, which is brilliant.’ But its success raises an issue for screening programmes, said Prof Lyng, who is head of the Radiation and Environmental Science Centre at the Technological University Dublin.

With fewer cases of pre-cancer and cancer cells presenting in the population, cytologists will not be so used to encountering these abnormalities, meaning their ability to spot them might decline. ‘That’s why people are interested in developing new methods (like Raman spectroscopy) which are more objective,’ said Prof Lyng.

There are ‘horrific stories of young women dying from this disease. That shouldn’t happen because it’s so treatable – if it’s detected at that early stage of pre-cancer,’ said Prof Lyng.

Results so far indicate that Raman spectroscopy is more accurate than cytology.

‘All tests have false positives and false negatives, and Raman is not 100% accurate either. But it does have a higher sensitivity than cytology, so we think it would improve outcomes for women by detecting cancers, or pre-cancers, earlier,’ said Prof Lyng.

The research in this article was funded by the EU. This article was originally published in Horizon, the EU Research and Innovation Magazine.  

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Lost for words – the devastation caused by aphasia

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by Vittoria D’Alessio

Aphasia is a devastating diagnosis that affects your ability to speak or understand language. It’s a little-known condition that effects 300 000 Europeans every year and recently made headlines when actor Bruce Willis announced he was diagnosed with it.

Aphasia is a language disorder that is caused by a brain damage to the part of the brain that controls language. It often arises as a result of a stroke, brain tumour or a neurodegenerative disease, such as Alzheimer’s.

The Hollywood actor and star of Die Hard, Bruce Willis recently announced his retirement following a diagnosis of aphasia. The condition affects a person’s ability to speak or understand coherently.

Many had never heard of aphasia before learning this sad news, which is perhaps surprising given there are 300 000 new cases in the EU every year.

Devastating diagnosis

‘People tend to focus on the underlying causes,’ said Dr Nicoletta Biondo, a psycholinguist at the University of California, Berkeley, ‘But not being able to communicate can be devastating – you wake up one day to find you’ve lost part of your capacity to speak or understand.’

She added, ‘Aphasia is really unexplored territory, but we’re starting to see more research in this area. We hope this will give us a better understanding of how the language system works and provide scientific bases for therapies that can give people a better quality of life.’

Damage to any part of the brain that facilitates language can result in aphasia. The nature of the symptoms is determined by the location and size of the injury.

Some people with aphasia may simply not remember the word for ‘orange’. Others may be able to write ‘orange’ but not read it back. Others may say ‘apple’ instead of ‘orange’ and insist they are right. There are those who may attempt to say ‘orange’ but the sound they produce bears no resemblance to the word. A further subset is unable to repeat ‘orange’ after it’s said to them. And yet another group simply doesn’t understand the meaning of ‘orange’.

Sub-types

‘With better diagnostic tools, we’ll be able to determine which sub-type of aphasia a person is suffering from, and clinicians will be able to direct patients to the correct therapy without wasting time’, said Dr Seçkin Arslan, a neurolinguist leading the EU-funded research project ProResA, which aims to better understand the connection between pronoun usage and aphasia. ‘Currently there is no way to stop aphasia but there are therapies to maintain language abilities for longer.’

Primary progressive aphasia (PPA) is a relatively rare form of the condition, though the prevalence is rising in an ageing society. Generally, it is brought on by a stroke or progressive brain degeneration (for instance in those with dementia).

People with PPA often show an unusual use of pronouns (words like you, she and it) instead of saying the name of a person or object, they opt for the generic pronoun.

‘Pronoun processing can be difficult because it requires a well-functioning memory. After hearing a noun or name, you must reactivate the memory trace of the thing or person you’re talking about,’ said Dr Arslan, adding, ‘It’s not that pronouns are the most important aspects of grammar, but they are a small detail that can be used to test how disease or a stroke have impacted general language abilities.’

The ProResA team aim to better understand the ‘markers’ of aphasia and to develop tools that precipitate a diagnosis of aphasia. They will predict who will develop aphasia even before there are obvious signs of the condition and enable degenerative brain disorders, like Alzheimer’s, to be identified earlier.

Currently, standard international tests to diagnose and grade aphasia are only available in English, making it impossible to compare the severity of the condition across all countries.

To date, the EU-funded Collaborations of Aphasia Trialists and their many international collaborators have adapted standard aphasia assessment tools into 15 languages. 

Eye-tracking

For the first time, data are being collected using eye-tracking technology – a tool that has already proven useful in dementia diagnosis. Typically, people who go on to develop Alzheimer’s disease show signs of eye movement impairment before any cognitive symptoms appear.

Participants participate in a “visual world paradigm”, listening to a series of sentences while looking at pictures on a computer screen. When there’s a match between spoken word and image, the participant clicks a mouse.

An infrared camera shoots a beam at the subject’s eyes, which allows the flickering eye movement to be tracked. The camera records where a person looks at the screen and for how long. The accuracy of each “fixation”, the time taken to analyse an image, and the speed of the mouse click are recorded.

‘If we can eventually develop a database of people with PPA by tracking their eye movement while they are processing language, we will have a predictive tool for people with milder dementia who will go on to develop aphasia’, said Dr Arslan.

Brain damage

A separate strand of ProResA focuses on using magnetic resonance imaging (MRI) to identify those areas of the brain that are not functioning properly. They will create a detailed map of brain damage and its correlation with specific types of language impairment.

T.I.M.E is another European project using MRI. Dr Biondo, who leads the project, is focused on identifying the brain areas and networks that cause time impairment.

Some people with aphasia speak ‘telegraphically’, using phrases without verbs that give no sense of time. ‘We say a lot with a verb – it’s the core of a sentence and conveys important time-related information, said Dr Biondo. But when someone says “I breakfast”, we don’t know if this thing happened in the past, will happen in the future or is happening now.’

Very little is known about why this happens, though some believe the problem is not purely linguistic but relates to difficulty conceptualising an event that isn’t happening now.

Simple tasks

Dr Biondo will be setting patients simple tasks (like putting a series of photos of celebrities in age order) and correlating the results with brain scans that highlight the precise location of a lesion.

‘Once we have a better understanding of what is really going on, we can try to help people in a more meaningful way – for instance, we can work on practical ways to train the brain to recover or regain whatever loss there has been.’

The research in this article was funded by the EU. This article was originally published in Horizon, the EU Research and Innovation Magazine.  

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Health & Wellness

Why Students Should Have Sports Pauses Between Lectures

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Including physical activities and exercise in your day can provide some great benefits. As a student, you may have a busy schedule that can make it difficult to engage in healthy habits. However, playing sports between lectures or being involved in a college team on campus has many benefits. Unfortunately, some students report that walking is their daily exercise. While this does help keep the body moving, it is not enough to meet today’s standards.

Here, we look at how a student, and even teachers, can benefit from playing sports between their lectures and classes. Whether it is done on campus or at a gym with peers, including fitness exercise is one of the ways to ensure your body and brain remain healthy.

Aerobic Exercise for Brain Health

As a college student, it can be hard finding the time to include sports in a schedule. However, playing sports and adding exercise are essential for brain function. While trying to juggle attending classes, completing coursework, and writing essays, students may need to find some extra help. With essay writing services, one can get assistance with essays, research papers, homework, and more. Students can free up some time and still maintain their grades. Asking for help does not mean failure. It can be a great way for any struggling student to learn how to spell for good grades, meet strict deadlines, and more.

During that extra time, getting involved in sports between classes or lectures can be very beneficial. This can positively affect a protein called BDNF, which promotes the growth of nerve cells. Types of aerobic exercise will also help with heart health and can enhance your mindset. It will improve alertness and attention, allowing students to learn and retain information easier. This can help those that struggle with writing essays or a research paper. Adding exercise or playing low-impact sports could boost motivation so that students can complete their next assigned essay on their own.

Help with Stress and Anxiety

Stress is something that every student will deal with. They have to complete courses, write essays, and even rewrite papers based on teacher comments on students’ writing. This all takes up time and can lead to great levels of stress. There have been studies conducted on how engaging in sports activities can reduce these things. By taking a time-out period during the day to exercise, daily stressors can be reduced. During this time, engaging in a low-intensity workout can effectively reduce anxiety and stress.

Aerobic exercise will help one rebuild confidence and alleviate some anxiety. When exercising, there will be reduced muscle tension, and it teaches one to look for different situations that provoke stress or anxiety. Many students stress or have anxiety over their grades. If you have a student contract for grades in college, there is an agreement between you and the professor on grading papers a bit differently. Even though you may have this contract, stress will always be a factor when completing assignments. Taking some time to play sports on campus between classes or study sessions can help with this.

Improves Sleep

Whether you are a student tackling courses or a teacher grading college papers, getting a good night’s sleep is essential. Having some type of physical routine and exercising will help to improve sleep quality. Those who play sports will also be able to fall asleep faster. While sleeping, the brain is always working and retaining information from studying. Not getting enough sleep can lead to decreased attention in class. By getting in a good 8 hours, higher brain functions will not be impaired, allowing you to be a better student and maintain good grades.

To get the most from exercise, try to schedule workouts, practices, or scrimmages in the morning or afternoon. If you exercise too close to when you go to sleep, your body temperature may be too high, resulting in the inability to fall asleep.

How to Incorporate Exercise

If you are one that does not regularly exercise but you want to start enjoying the benefits, there are some ways to easily add a routine to your schedule. Students have many things to worry about when attending a university. Staying healthy and having good brain function are usually not things that many think of. However, they are essential to your academic success. If you are ready to include exercise, here are some tips that can be useful:

·        Save Money – Money is the main concern for any student, and not everyone can afford a gym membership. There are some free or inexpensive ways to have access to what is needed for a good workout. Buying or borrowing resistance bands, exercise balls, or jump ropes are just a few examples.

·        Make a Schedule – Just like you have a schedule for classes and homework, having one for sports is also needed. This will allow you to set aside specific time slots for playing a game or getting in practice, making it a priority. Experts suggest performing exercise regimes in the morning, so there are no excuses for procrastination later in the day.

·        Make Lifestyle Adjustments – Making small changes during the day can help achieve exercise goals. Choose to take the stairs instead of escalators, walk or bike around campus, and add a walk during study breaks instead of snacking or socializing.

·        Join School Activities – There are many others who are looking to stay healthy and keep fit. Some schools have activities that include programs and classes. These are held on campus, so they provide easy access and allow for interaction with peers. Every college will have a wide array of sports that can be enjoyed. You can join teams representing your university or play some social games with others.

Conclusion

Academic performance is the main focus for college students, but it is not everything. Your general health should also be a concern. You will need to be mentally and physically healthy so you can benefit from those good grades that are being earned. There is no need to take part in rigorous training sessions or intense sporting activities. Simple activities can promote a healthy body and mind, and many activities can be found right on campus.

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