From chewing sticks to using twigs, hog bristles and horsehair, people have been polishing their pearly whites for millennia. Now EU scientists are investigating whether good oral hygiene can also protect us from chronic lung diseases. They’re also checking what our saliva says about our overall health.
Did you ever think that a simple task like brushing your teeth could actually keep your lungs healthy – in addition to preventing cavities and gum disease?
The bacteria causing gum disease have already been linked to life-threatening heart illnesses for a while now. It is suspected they enter the bloodstream and travel to the heart. This would explain why some microbes from dental plaque often turn up in heart valves and heart muscle.
There is now increasing indication that gum health may be also strongly linked to lung diseases. ‘We believe that inflammatory bacteria in the mouth create pockets between the gum and tooth, break down the lining and spread to the heart and lungs,’ said Dr Randi Bertelsen at the University of Bergen in Norway.
Whether the bacteria in our mouth influence the health of our lungs and future risk of lung disease is the focus of a project that Dr Bertelsen leads. This involves hundreds of participants in a previous study (the European Community Respiratory Health Survey, ECRHS) who were monitored for respiratory health over the last two decades and who had given samples from their gums around 10 years ago. With further research now underway under the BRuSH project, Dr Bertelsen is investigating the role played by the oral microbiome in lung disease. Her hypothesis is that oral microbiome communities dominated by bacteria will have a negative effect on the respiratory tract.
The patient journey through time may help reveal whether deteriorating dental health is indeed a preamble to lung disease, indicating that bacteria in the mouth are detrimental to lung health, or not. The patient gum samples were collected in study centres in Bergen, Norway; Tartu, Estonia; and Melbourne, Australia as part of ECRHS III. Dr Bertelsen is especially interested in asthma and chronic obstructive pulmonary disease (COPD), two incurable lung diseases.
Gum-lung health link
‘Most chronic lung diseases are characterised by inflammation, with lots of mucus, which makes it hard to breathe,’ Dr Bertelsen states. ‘This inflammation is caused by Gram-negative bacteria.’ So named because they don’t take up a violet-coloured dye (from Danish microbiologist Hans Christian Gram). BRuSH is especially interested in those bacteria.
Periodontitis, more commonly called gum disease, is a common bacterial infection that involves severe inflammation in the gums and can even destroy the jawbone supporting the teeth. It is estimated that more than half of European adults suffer from some form of periodontitis, many without realising it. Some bacteria found in infected gum as well as heart tissue, such as Porphyromonas gingivalis and Streptococcus mutans, produce a compound known as lipid A. This comes in a range of chemical forms, one of which is especially potent at causing inflammation attributed to Gram-negative bacteria.
It is already known that patients with severe lung disease, such as COPD, often have severe gum disease too, but it is unclear which comes first. To resolve this, the BRuSH project will investigate by enrolling young patients with mild to moderate gum disease. Dentists will treat away bacteria from their mouth – the traditional treatment for periodontitis. Saliva and blood samples will be taken before and after the procedure.
‘We want to see if removing the bacteria in a relatively young population, before they have any respiratory diseases, actually improves lung function,’ said Dr Bertelsen. If removing the bacteria leads to better lung health, this will demonstrate that oral hygiene is far more important for lung health than previously thought. This would underline just how important tooth brushing, flossing between teeth, and dental visits are in young adults for their future lung health.
‘In Norway, healthcare is free, but going to the dentist is very expensive,’ said Dr Bertelsen, ‘and young adults in their 20s might not go for check-ups unless something is wrong.’ She worries that the consequences may be a build-up of bacteria that secrete toxins that are detrimental to their lung health over time and may promote lung diseases.
Will saliva tests replace blood tests?
Don’t take your saliva for granted. It says a lot about your health. As indicated, bacteria present in saliva might one day inform researchers about the future lung health, but also other diseases too. And although it is routine to take blood samples from patients, doctors in future may learn about their patient’s health simply by taking a mouth swab. The idea is for the saliva to be tested there and then, without the need for sophisticated and expensive lab tests.
‘There is an urgent need for very sensitive and simple sensors that could be used in the dentist or a doctor’s office or even a patient’s home,’ said Professor Bojan Petrovic, dental scientist at the University of Novi Sad in Serbia. This would allow more people to be tested and diagnosed, easier and faster, and thereby receive any appropriate treatment earlier. Petrovic is involved in a research project (SALSETH) that seeks to use tiny amounts of saliva, with just a few reagents, to run fast and inexpensive tests using advances in microfluidics – the precise control of miniscule amounts of fluids in microchannels.
There are many diseases and infections where tiny drops of saliva could tell doctors about the health of their patients more rapidly and less invasively than taking a blood test and sending it for analysis. ‘Numerous viral infections such as hepatitis A, B, C; Epstein-Barr virus; and herpes virus have their detectable biomarkers in salivary samples,’ explained Prof. Petrovic. ‘Saliva serves as a valuable diagnostic fluid for the early detection of different cancers such as breast cancer, pancreatic cancer, lung and gastric cancer.’
The scientists working on the SALSETH project, which is both international and intersectoral, believe that saliva could also be used to assess the levels of the male sex hormone testosterone or the stress hormone cortisol. It could allow for easier monitoring of women on hormone replacement therapy, and it might also allow for some autoimmune conditions to be detected, including celiac disease, cystic fibrosis or Sjogren’s syndrome.
‘Saliva is frequently called the mirror of the body,’ Prof. Petrovic concluded, and it is ‘readily available and easily collected and stored.’ Advances in microfluidics and the research by scientists as part of the SALSETH project should help usher in new sensors, including ingestible sensing capsules designed to detect some diseases.
Without a doubt, your mouth is a mirror of your health. Not brushing your teeth will likely get you in trouble with the dentist – but could result in even bigger health risks. How and why remains to be seen, but the important work being carried out by EU researchers is expected to shed light on the intricate mechanisms bringing together bacteria, saliva and the origination and development of disease in different areas of our body.
The research in this article was funded by the EU. This article was originally published in Horizon, the EU Research and Innovation Magazine.
Why more heatwaves endanger our health and ability to work
As the Earth warms, heatwaves are expected to occur more often, with sharper intensity and for longer periods. Rising temperatures adversely affect worker productivity and human health, but for policymakers to take substantive action for heat adaptation, and meet what researchers see as a life-saving Paris climate agreement, making an economic case is key.
BY NATALIE GROVER
As the Earth warms, heatwaves are expected to occur more often, with sharper intensity and for longer periods. Rising temperatures adversely affect worker productivity and human health, but for policymakers to take substantive action for heat adaptation, and meet what researchers see as a life-saving Paris climate agreement, making an economic case is key. This article first appeared in Horizon Magazine in August 2020.
It’s actually quite easy for us to point out the problem — we have increasing temperatures, increasing frequency of heatwaves…it affects our physical and cognitive performance,’ said Lars Nybo, a professor of integrative physiology from the University of Copenhagen, Denmark. He worked on a project called HEAT-SHIELD designed to examine the effects of heat exposure on worker productivity in industrial sectors that employ half of Europe’s workforce: manufacturing, construction, transportation, tourism, and agriculture. The project ran from January 2016 until December 2021.
Globally, 2021 was among the seven hottest on record, with Europe experiencing its hottest summer to date. In the Mediterranean region, an intense and prolonged heatwave in July and August lead to new temperature records and devastating wildfires, a poignant reminder that the achievement of the Paris climate agreement to keep global mean temperature increases well below 2°C is as important as ever.
Data from HEAT-SHIELD project suggest that exposure to external heat in combination with physical activity, which elevates the body’s production of heat, can result in physiological changes that can diminish occupational performance, via reduced working endurance, vision, motor coordination and concentration. This can lead to more mistakes as well as injuries.
‘Roughly 70% of all European workers, at some time during the working day, are not optimally hydrated,’ Prof. Nybo said. The solution to the problem, he added, is intuitive: drink water, replace electrolytes and reduce physical activity, but implementing these measures whilst maintaining productivity is where things get tricky.
‘You could just say to the worker stay at home and drink cold margaritas in the shadow to prevent heat stress,’ he joked. ‘But that will not help productivity.’
As coordinator of HEAT-SHIELD, Prof. Nybo and his team were tasked with not just assessing the extent of the problem — modelling the expected rise in temperature in Europe in the coming years and its impact on worker productivity — but also devising and implementing solutions that are location and vocation specific to adjust to the inevitable increases in temperature.
A construction worker wears a safety helmet, which impairs the body’s ability to purge heat, but the worker thinks this problem cannot be solved because it is intrinsic to their work, Prof. Nybo noted.
Surmounting challenges like this was one of the key objectives of the project — conceiving ways to weave in heat mitigation strategies alongside the practicalities of the job.
For instance, outdoor workers should be vigilant of weather patterns and plan work earlier in the day during periods of extreme heat, take a short break every hour and secure easy access to water. Similar remedies for workers in enclosed settings could mean a combination of air conditioning, working in shade and improving ventilation — keeping in mind the ecological footprint of such measures.
But on a macro level, for climate change policymakers to take concrete action here and now — the numbers are key, Prof. Nybo said.
In Europe, agricultural and construction workers for instance, lose some 15% of effective working time when the temperature goes beyond 30°C, which works out to almost one working day per week, he noted, citing HEAT-SHIELD analyses.
If you are a policymaker, he says, the numbers show that there’s an incentive to act now: if you mitigate the problem the cost will stabilise at a lower level in the long run than if you don’t.
Diminished worker productivity and the downstream economic damage are prominent impacts of rising temperatures caused by climate change. But to get a full picture of the consequences, it’s necessary to understand what excessive heat does to the human body.
It can damage organs such as the heart and the lungs, exacerbate a range of diseases, and increase the risk of death.
Extreme heat can increase the occurrence of heart attacks and strokes in susceptible patients due to increased blood viscosity, and raise the risk of cardiovascular death in vulnerable patients. Hot, humid days can also trigger asthma symptoms and have been shown to increase airway resistance, while warmer climates tend to extend the pollen season.
Another side effect of rising temperatures is the association with air pollution — the largest environmental killer in Europe, causing roughly 500,000 premature deaths annually.
Observational data and modelling suggest that as it gets warmer, air pollution levels — particularly surface ozone gas (O3) and fine particulate matter (PM2.5) — increase in some populated regions, even when emissions of air pollutants have not risen, as well as create conditions favourable for forest fires.
Both extreme heat and air pollution raise the risk of cardiovascular and respiratory disease, which currently costs the European Union an estimated €600bn a year. If these environmental stressors continue to accumulate unabated, these costs could jump.
But the synergistic relationship between air pollutants and rising temperatures is not well understood and existing health-risk projections in Europe do not properly account for adaptive measures that can be taken to ameliorate associated health risks, according to Dr Kristin Aunan, a senior researcher at the Norway-based Center for International Climate Research.
‘There’s quite a lot of literature on short-term impact — in terms of the day-to-day variation on the impact of heat stress on mortality — but when it comes to long-term impact, there is not a lot of information,’ she said.
As part of a project called EXHAUSTION that kicked off in 2019 and is due to run until May 2023, researchers including project coordinator Dr Aunan, are focused on quantifying the risks of cardiopulmonary disease in different temperatures.
The project is also working on identifying interventions to minimise the risks to health sparked by environmental stressors and demystifying the link between air pollution and temperature hikes.
Quantifying the cascading effect of cardiopulmonary diseases on the economy is key to affecting action on climate change, she suggests.
EXHAUSTION researchers, for instance, are devising a macro-economic model that tracks increased hospitalisation and mortality in different age groups to measure the impact on the broader economy in different European countries. ‘We also have a bottom-up model — where you put a price on every premature death or hospital admission and add up to estimate the economic cost.’
One of the main questions the researchers hope to answer is the magnitude of impact limiting temperature spikes to 1.5°C — the aim of the Paris climate agreement — will have on health.
‘I have no answer to that today — but the reason why we’re doing this project…is that we think there are reasons to believe that being able to comply with a Paris agreement will save very many lives and reduce human suffering,’ Dr Aunan said.
‘When you discuss climate policy and discuss the costs of it — it’s very expensive to reduce emissions of greenhouse gases, etc. But you also need to consider the benefits and that’s what we are doing with this project — hoping that we can contribute to the other side of the coin.’
This article first appeared in Horizon Magazine in August 2020.
Children at risk of new ‘unexplained acute hepatitis’ outbreak
The world is currently facing a new outbreak of “unexplained acute hepatitis infections” affecting children, the World Health Organization (WHO) warned on Thursday, World Hepatitis Day.
The current uptick focuses attention on the thousands of acute viral hepatitis infections that occur every year among children, adolescents, and adults.
WHO, together with scientists and policymakers in affected countries, are working to understand the cause of this infection that does not appear to belong to any of the known five types of hepatitis viruses: A, B, C, D, and E.
While the world has the guidance and tools to diagnose, treat, and prevent chronic viral hepatitis, these services are often out of reach for communities and are sometimes only available at centralized or specialized hospitals.
“To be most effective, hepatitis care must be delivered in communities through strong primary healthcare and integrated with other health services that address the full range of health needs,” WHO chief Tedros Adhanom Gebreyesus said in his message for World Hepatitis Day.
Although most acute infections cause mild disease and even go undetected, some can lead to complications and turn fatal.
In 2019 alone, complications of acute hepatitis A to E infections caused an estimated 78,000 deaths worldwide.
Global efforts prioritize the elimination of hepatitis B, C and D infections.
Unlike acute viral hepatitis, B, C and D cause chronic disease, which lasts for several decades, culminating in over one million deaths per year from cirrhosis and liver cancer. And they are responsible for over 95 per cent of hepatitis deaths.
Death every 30 seconds
“Every 30 seconds, someone dies from hepatitis-related diseases, including liver failure, cirrhosis and cancer,” said the WHO chief.
Moreover, some 80 per cent of people living with the disease are unable to access or afford care.
With the goal of eliminating hepatitis by 2030, the UN health agency has called on countries to reach four specific targets.
It aims to reduce new infections of hepatitis B and C by 90 per cent; reduce hepatitis-related deaths from liver cirrhosis and cancer by 65 per cent; ensure that at least 90 per cent of people with hepatitis B and C virus are diagnosed; and at least 80 per cent of those eligible, receive appropriate treatment.
“Low coverage of testing and treatment is the most important gap to be addressed, in order to achieve the global elimination goals by 2030,” according to WHO.
Call to action
WHO is calling on all governments and partners to “scale up the use of effective tools” against the potentially deadly disease.
Tedros drew attention to a new WHO report that shows how Brazil, Egypt, Georgia, Mongolia, Rwanda, Thailand and the United Kingdom, are making progress towards the elimination of hepatitis B and C by applying the UN health agency’s tools and guidelines.
“With political commitment and investment, the elimination of viral hepatitis is within our reach,” he stated.
The day aims to raise awareness of viral hepatitis, which causes inflammation of the liver that leads to severe disease and liver cancer.
It also offers an opportunity to step up national and international efforts on the infection, encourage individuals, partners and the public to act, and highlights the need for a greater global response, as outlined in the WHO’s Global hepatitis report of 2017.
This year, WHO is highlighting the importance of bringing hepatitis care closer to primary health facilities and communities for better access treatment, no matter the type of hepatitis.
The 28 July date was chosen because it is the birthday of Nobel-prize winning scientist Baruch Blumberg, who discovered hepatitis B virus (HBV) and developed a diagnostic test and vaccine for the virus.
Tone as important as truth to counter vaccine fake news
By ALEX WHITING
Lack of trust in health authorities, combined with the fear and uncertainty about the disease, created fertile ground for false rumours to spread about Covid-19 vaccines. Countering the rumours may be about attitude as well as facts.
False assertions about Covid-19 vaccines have had a deadly impact – they are one reason why some people delayed being inoculated until it was too late. Some still refuse to be vaccinated.
More than two years after the start of the pandemic, false rumours continue to circulate that the vaccines do not work, cause illness and death, have not been properly tested and even contain microchips or toxic metals.
Now a study raises hopes of deflecting such falsehoods in future by changing the tone of official health messaging and building people’s trust.
In many countries, public confidence in government, media, the pharmaceutical industry and health experts was already on the wane before the pandemic. And in some cases, it deteriorated further during the rollout of Covid vaccines.
This was partly because some national campaigns said the jabs would protect people from falling ill.
Friends over facts
‘There was a lot of overpromising around the vaccine without really knowing what would happen,’ said Prof Dimitra Dimitrakopoulou, research scientist and Marie Curie Global Fellow at the Massachusetts Institute of Technology and the University of Zurich.
‘Then people started getting sick, even though they were vaccinated. That created a lack of trust in the government issuing these policies, and in the scientific community.’
Prof Dimitrakopoulou studied public perceptions of Covid vaccines and obstacles to acceptance of reliable information as part of a project called FAKEOLOGY.
She found that, when people lose faith in institutional sources, they end up relying only on themselves, close friends and family.
‘They trust their instincts, they trust what resonates with them,’ Prof Dimitrakopoulou said. That means they will search the internet, social media and other sources until they find information that reinforces the beliefs they already hold.
‘We have lived with fake news and misinformation long enough to understand that it cannot be debunked with facts,’ she said. ‘People just raise these emotional blocks.’
For example, a story about a mother whose child fell sick after getting a Covid vaccination would likely be more influential than a message containing scientific facts.
Prof Dimitrakopoulou surveyed 3 200 parents of children under 11 years old in the United States, and conducted focus groups with 54 of them, to discuss their views about Covid vaccines for kids.
Many parents felt confused by conflicting information about the shots and had a lot of questions about their effectiveness.
She gave the parents a selection of messages to assess. They were put off by the ones that were largely factual, rigid and prescriptive – the tone of many public health campaigns.
They were more persuaded by messages that addressed their concerns about the vaccines with empathy and compassion while acknowledging that they face a difficult decision.
‘We need to be ready to answer any questions they may have and be ready to have a conversation – without expecting the conversation to end with someone getting vaccinated,’ said Prof Dimitrakopoulou.
Those exchanges will ultimately help bolster public faith in health bodies and government institutions. ‘Covid is a great opportunity for us to start building this trust,’ she said.
While a lengthy process, building these bridges could enlighten people’s perceptions for the rest of their lives, she said.
Fake news filter
It is also important for journalists, researchers and the general public to be able to spot and filter out fake news.
Researchers on a project called SocialTruth have developed a tool to flag fake news content on the internet and social media.
The software, called a Digital Companion, can check the reliability of a piece of information. It analyses the text, images, source and author and, within two minutes, produces a credibility score – a rating of between one and five stars.
‘This is a computer-generated score that can give a red-flag warning if the content is very similar to other types of content that have been found to be false,’ said Dr Konstantinos Demestichas, researcher at the Institute of Communication and Computer Systems in Athens and coordinator of SocialTruth.
The Digital Companion uses computer algorithms that draw on a wide variety of verification services. These include non-governmental organisations, businesses and academic institutions – all with different interests, opinions and intentions.
Because of the diversity of verification-service providers, ‘We need to establish their trustworthiness by continuously evaluating their results,’ said Dr Demestichas.
To do this, the project uses blockchain to record all the scores and results produced by the verifiers. If the verifiers perform poorly, they lose their status – ensuring the Digital Companion can offer a quality assurance, he said.
Digital and human fact checkers
For now, the technology has been developed to scan health science and political content. In future, it could be developed for almost all areas.
Initially it will be for institutions that monitor fake news and disinformation, but the aim is to enable journalists and the general public to take advantage of the resource too.
The technology ‘could really make a difference in the daily use of the internet and social media,’ said Dr Demestichas.
Still, because it will never be able to spot all fake news, ‘We need journalists, fact checkers, and citizens to be well-trained to exercise their critical thinking,’ he said.
The fight against misinformation is about more than protecting people’s health, important as that is. The well-being of democratic societies themselves is also at stake, said Dr Demestichas.
‘Fake news tries to manipulate our feelings and fears to get our “clicks” to read their content,’ he said.
Curbing it is critical ‘to defend our democracies and allow our societies to function better.’
The research in this article was funded by the EU. This article was originally published in Horizon, the EU Research and Innovation Magazine
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