China is among three additional countries to have signed on to a global initiative that aims to ensure fair and equitable access to a COVID-19 vaccine once developed, the World Health Organization (WHO) reported on Friday.
The country, together with the Republic of Korea and the tiny Pacific island of Nauru, joined the COVAX Facility this week, bringing the total number of participating nations and economies to 171, WHO chief Tedros Adhanom Ghebreyesus announced during his regular media briefing on the pandemic.
“Once we have an effective vaccine, we must also use it effectively, and the best way to do that is by making sure it’s available to all countries equitably through the COVAX Facility.”
More countries, greater prospects
The global mechanism will work to deliver two billion doses by the end of next year. It currently has the largest portfolio of potential vaccines, with several in advanced human trials.
WHO was asked about the impact of China’s participation.
“The more countries that participate in the COVAX Facility, the greater opportunity of being able to roll out vaccines as rapidly as possible, as fairly as possible, to reduce the risk of severe COVID disease globally”, said Dr. Bruce Aylward, Senior Advisor.
He added that details on China’s enrollment “(are) still being worked out”, with specific information anticipated early next week.
Notably, both the United States and Russia have not so far signed on.
A sign of solidarity
WHO has also welcomed the announcement this week that vaccine developer Moderna will not enforce patent rights over its COVID-19 shots during the pandemic.
Tedros expressed appreciation for “this act of solidarity”, which aligns with another initiative for sharing scientific knowledge, data and intellectual property in efforts to beat back the disease.
The COVID-19 Technology Access Pool (C-TAP) was launched in May and is described as a “one-stop shop” for affordable access to technology.
It draws on existing mechanisms such as the UN-backed Medicines Patent Pool, which expands access to treatments for HIV and hepatitis for low and middle income countries.
Praise for the World Food Programme
Tedros began the briefing by congratulating sister UN agency the World Food Programme (WFP), which was awarded the Nobel Peace Prize earlier on Friday.
His praise was echoed by Dr. Michael Ryan, Executive Director of WHO’s Health Emergencies Programme, who has worked in conflict areas and led many responses to epidemics, including containing Ebola in the Democratic Republic of the Congo.
“WFP not only feeds the hungry but moves most of the humanitarian workforce into the most extreme of environments,” Dr. Ryan told journalists.
“WFP feeds and protects us in the field and allows us to do our job. We used to say this in West Africa, and I will say it to the world: WFP rocks”.
UN-backed COVAX mechanism delivers its 1 billionth COVID-19 vaccine dose
With a 1.1 million jab delivery in Rwanda this weekend, the World Health Organization’s multilateral initiative to provide equal access to vaccines for all reached the one billion milestone.
Along with the Coalition for Epidemic Preparedness Innovations (CEPI), the Vaccine Alliance GAVI, and partners, WHO has led the largest vaccine procurement and supply operation in history with deliveries to 144 countries to date.
According to a press release published on Sunday, as of 13 January 2022, out of 194 countries members of WHO, 36 have vaccinated less than 10% of their population, and 88 less than 40%.
“COVAX’s ambition was compromised by hoarding/stockpiling in rich countries, catastrophic outbreaks leading to borders and supply being locked. And a lack of sharing of licenses, technology, and know-how by pharmaceutical companies meant manufacturing capacity went unused”, the agency explained.
On 24 February 2021, Ghana became the first country in the world to receive vaccines through COVAX when 600,000 doses of the Oxford–AstraZeneca vaccine were delivered to Accra.
The work that remains
COVAX is currently working with governments, manufacturers and partners to ensure that when countries receive vaccines, they can get them to people quickly.
“The work that has gone into this (1 billion) milestone is only a reminder of the work that remains”, the UN’s health agency underscored.
They added that with updated vaccines in the pipeline, citizens should demand that governments and pharmaceutical companies share health tools globally and “bring an end to the death and destruction cycles of this pandemic, limit new variants and drive a global economic recovery”.
COVAX is one of three pillars of the Access to COVID-19 Tools (ACT) Accelerator, which was launched by WHO in April 2020 in response to the pandemic.
The ACT Accelerator is a ground-breaking global collaboration to accelerate the development, production, and equitable access to COVID-19 tests, treatments, and vaccines.
WHO recommends two new drugs to treat patients with COVID-19
The World Health Organization (WHO) on Thursday reccommended two new drugs to treat patients with COVID-19, one for patients with critical disease, and another deemed effective for non-severe cases.
The first drug, baricitinib, is a Janus kinase (JAK) inhibitor- a class of drugs used to treat autoimmune conditions, blood and bone marrow cancers, and rheumatoid arthritis.
According to the WHO Guideline Development Group, it is “strongly recommended” for patients with severe or critical disease in combination with corticosteroids.
The group of international experts based their recommendation on “moderate certainty evidence” that it improves survival and reduces the need for ventilation.
There was no observed increase in adverse effects.
The experts note that it has a similar effectas other arthritis drugs called interleukin-6 (IL-6) inhibitors. Because of that, when both drugs are available, they suggest choosing the best option based on cost, availability, and clinician experience.
It is not recommended to use both drugs at the same time.
The experts also advise against the use of two other JAK inhibitors (ruxolitinib and tofacitinib) for patients with severe or critical cases of COVID-19 infection.
According to them, trials undergone using these drugs failed to show any benefits arising using either drug,and suggested a possible increase in serious side effects with tofacitinib.
In the same update, WHO makes a conditional recommendation for the use of a monoclonal antibody known as sotrovimab in patients with non-severe cases.
According to them, the drug should only be administered to patients at the highest risk of hospitalisation. In those at lower risk, it onlyshowed “trivial benefits”.
A similar recommendation has been madepreviously, for another monoclonal antibody drug, casirivimab-imdevimab, and the experts say there is insufficient data to recommend one over the other.
For both, the effectiveness against new variants, like Omicron, is still uncertain.
The group will update their guidelines for monoclonal antibodies when more data becomes available.
These recommendations are based on new evidence from seven trials involving over 4,000 patients with non-severe, severe, and critical infections.
Developed by WHO with the methodological support of MAGIC Evidence Ecosystem Foundation, the guidelinesprovide trustworthy guidance and help doctors make better decisions with their patients.
According to the agency, the guidelines are useful in fast moving research areas, because they allow researchers to update evidence summaries as new information becomes available.
The latest guidance also updates recommendations for the use of interleukin-6 receptor blockers and systemic corticosteroids for patients with severe or critical COVID-19; conditional recommendations for the use of casirivimab-imdevimab (another monoclonal antibody treatment) in selected patients; and against the use of convalescent plasma, ivermectin and hydroxychloroquine, regardless of disease severity.
Omicron fuels record weekly COVID-19 cases, but deaths ‘stable’
Fuelled by Omicron, more than 15 million new cases of COVID-19 were reported around the world last week, by far the most cases reported in a single seven day period, the World Health Organization (WHO) informed on Wednesday.
Briefing reporters in Geneva, the UN health agency chief, Tedros Adhanom Ghebreyesus, said the “huge spike” is being driven by the Omicron variant, which is rapidly replacing Delta in almost all countries.
Despite the number of cases, the weekly reported deaths have “remained stable” since October last year, Tedros added, at an average of 48,000. The number of patients being hospitalized is also increasing in most countries, but it is not at the level seen in previous waves.
He told reporters this is possibly due to the reduced severity of Omicron, and widespread immunity from vaccination or previous infection.
‘50 thousand deaths too many’
For the WHO chief, while Omicron causes less severe disease than Delta, it remains a dangerous virus, particularly for those who are unvaccinated.
“Almost 50 thousand deaths a week is 50 thousand deaths too many”, Tedros said. “Learning to live with this virus does not mean we can, or should, accept this number of deaths.”
For him, the world cannot “allow this virus a free ride” when so many people around the world remain unvaccinated.
In Africa, for example, more than 85 per cent of people are yet to receive a single dose of vaccine.
“We cannot end the acute phase of the pandemic unless we close this gap”, he said.
Tedros then listed some progress towards reaching the target of vaccinating 70 per cent of the population of every country by the middle of this year.
In December, COVAX shipped more than double the number of doses it distributed in November. In the coming days, the initiative should ship its one billionth vaccine dose.
Some of the supply constraints from last year are also starting to ease, Tedros said, but there’s still have a long way to go.
So far, 90 countries have still not reached the 40 per cent target, and 36 of those countries have vaccinated less than 10 per cent of their populations.
Tedros also highlighted an interim statement from the WHO Technical Advisory Group on COVID-19 Vaccine Composition, released on Tuesday, stressing that further vaccines are needed that have a greater impact on preventing infection.
Until such vaccines are developed, the experts explained, the composition of current vaccines may need to be updated.
The Group also said that a vaccination strategy based on repeated booster doses is “unlikely to be sustainable.”
A heavy toll
According to Tedros, the overwhelming majority of people admitted to hospitals around the world are unvaccinated.
At the same time, while the immunizations remain very effective at preventing severe disease and death, they do not fully prevent transmission.
“More transmission means more hospitalizations, more deaths, more people off work, including teachers and health workers, and more risk of another variant emerging that is even more transmissible and more deadly than Omicron”, Tedros explained.
The sheer number of cases also means more pressure on already overburdened and exhausted health workers.
A study published last year showed that more than one in four health workers have experienced mental health issues during the pandemic. Data from several countries also show that many have considered leaving or have left their jobs.
On Tuesday, WHO hosted a global webinar, attended by clinicians from around the world, on the clinical management of the virus during pregnancy, childbirth and the early postnatal period.
As stated earlier in the pandemic, pregnant women are not at higher risk of contracting COVID-19, but if they are infected, they are at higher risk for severe disease.
“That’s why it’s vital that pregnant women in all countries have access to vaccines to protect their own lives, and those of their babies”, Tedros said.
The agency chief also called for pregnant women to be included in clinical trials for new treatments and vaccines.
He also stressed that, fortunately, mother to baby transmission in utero or during birth is very rare, and no active virus has been identified in breast milk.
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